Hopson Block, constructed in 1896, exemplifies Renaissance Revival architecture with its red-brick façade, golden brick accents, and terra-cotta quoining. The building's tall, round-arched windows and machicolations along the entablature are framed by decorative detailing, enhancing its architectural significance. Originally, the structure featured more elaborate masonry, but some elements were removed over time to reduce costs.

The building is named after George Bailey Hopson, a prominent local figure in Naugatuck during the late 19th century. Hopson was involved in various business ventures in Naugatuck. He was associated with the Naugatuck Malleable Iron Company, where he served as president. Under his leadership, the company expanded its operations, contributing to the town's economic growth. His business acumen and community involvement made him a well-known figure in Naugatuck during his time.

The Hopson Building was originally constructed as a meeting space for the Knights of Pythias, a fraternal organization, and was later owned by St. Michael's Episcopal Church. Today, the Hopson Block houses various businesses on the ground floor and residential apartments on the upper levels.

Designated as part of the Naugatuck Center Historic District on July 30, 1999.